According to estimates, cancer will be the leading cause of death globally in the year 2010.

The International Agency for Research on Cancer (IARC), founded at the World Health Assembly in September 1965, launched its hefty World Cancer Report in Atlanta in the United States yesterday (subs: Tuesday).

In 1965 cancer was widely considered to be a disease of westernised, high-resource, industrialised countries.

Today the situation has changed dramatically, with the majority of the global cancer burden now found in low- and medium-resource countries.

Peter Boyle, IARC Director said the continued growth and ageing of the world’€™s population would greatly affect the cancer burden. By 2030, it could be expected that there could be 27 million incident cases of cancer, 17 million cancer deaths annually and 75 million persons alive with cancer within five years of diagnosis.

‘€œThe greatest impact of this increase will fall on the low- and medium-resource countries. Such countries are, arguably, harder hit by cancer than the high-resource countries. These countries frequently have a limited healthcare budget and a high background level of communicable disease,’€ said Boyle.

 Cancer treatment facilities are not universally available and life-saving therapies are frequently unavailable for economic reasons in most African countries.

Boyle warned that the rapid increase in the cancer burden represented a crisis for public health and health systems worldwide.

A major issue for many countries, even among high-resource countries, would be finding sufficient funds to treat all cancer patients effectively and provide palliative, supportive and terminal care for the large numbers of cancers which will be diagnosed in the coming years.

Despite the negative prospects, Boyle said it was important to note there were prospects for cancer prevention in all resource settings.

Tobacco smoking is the best-understood major human carcinogen. One third of cancers in high-resource countries are caused by tobacco smoking, which also causes a large proportion of deaths from other chronic disease including vascular disease and chronic obstructive pulmonary disease.

Boyle warned that the worst of the tobacco epidemic has yet to materialise in low-resource countries. There is a 40 year temporal gap between big changes in tobacco prevalence in a population and the peak of the disease epidemic caused by this habit.

Modifiable risk factors for cancer have also been identified, including alcohol consumption, excessive exposure to sunlight, lack of physical activity, overweight and obesity, dietary factors, occupational exposures and chronic infection.

 Effective prevention will reduce the risk of cancer, and effective screening will allow many others to be successfully treated for their disease.

In low-resource countries, many common cancers such as primary liver cancer, cervix cancer, nasopharynx cancer, Kaposi Sarcoma and stomach cancer are caused by chronic infections with different agents.

In these circumstances, there are now prospects for prevention via vaccination for hepatitis B (liver cancer) and human papillomavirus (cervix cancer).

 The major issue in the poorest countries is delivery of the prevention action at a price that is affordable for the countries’€™ health systems.

Identification of risk factors for cancers is not a simple task, and delivering effective prevention can be even more difficult.

Boyle said that priorities must be identified to tackle the global cancer burden. Such priorities must include a focus on low- and medium-resource countries and the identification, delivery and evaluation of effective cancer control measures.

‘€œFocus should be on the four pillars of cancer control: prevent those cancers which can be prevented; treat those cancers that can be treated; cure those cancers that can be cured; and provide palliation whenever palliation is required,’€ said Boyle.


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